Our Technology
Cello Therapeutics, Inc. takes advantage of cutting edge technology to develop biomimetic cell membrane-coated nanoparticles for cancer drug delivery. Originating from Prof. Liangfang Zhang's academic lab at the University of California, San Diego, the cell membrane coating technology has been extensively studied and published in over 18 high impact academic journals: 
  
  1. Zhuang, J.; Ying, M.; Spiekermann, K.; Holay, M.; Zhang, Y.; Chen, F.; Gong, H.; Lee, J-H.; Gao, W.; Fang, R.; Zhang, L. "Biomimetic nanoemulsions for oxygen delivery in vivo", Advanced Materials 2018, in press.
  2. Wei, X.; Zhang, G.; Ran, D.; Krishnan, N.; Fang, R.; Gao, W.; Spector, S.; Zhang, L. "T cell-mimicking nanoparticles can neutralize HIV infectivity", Advanced Materials 2018, in press.
  3. Zhang, Q.; Dehaini, D.; Zhang, Y.; Zhou, J.; Chen, X.; Zhang, L.; Fang, R.; Gao, W.; Zhang, L. "Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis", Nature Nanotechnology 2018, in press.
  4. Esteban-Fernandez de Avila, B.; Gao, W.; Karshalev, E.; Zhang, L., Wang, J. "Cell-like micromotors", Accounts of Chemical Research 2018, 51, 1901-1910.
  5. Luk, B.; Jiang, Y.; Copp, J.; Hu, C-M.; Krishnan, N.; Gao, W.; Li, S.; Fang, R.; Zhang, L. "Biomimetic targeting of nanoparticles to immune cell subsets via cognate antigen interactions", Molecular Pharmaceutics 2018, 15, 3723-3728.
  6. Zhang, G.; Luk, B.; Hamidy, M.; Zhang, L.; Spector, S. "Induction of Na+/K+-ATPase dependent form of autophagy triggers preferential cell death of human immunodeficiency type-1-infected macrophages", Autophagy 2018, 14, 1359-1375.
  7. Chen, Y.; Chen, M.; Zhang, Y.; Lee, J. H.; Escajadillo, T.; Gong, H.; Fang, R.; Gao, W.; Nizet, V.; Zhang, L. "Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges", Advanced Healthcare Materials 2018, 7, 1701366.
  8. Angsantikul, P.; Thamphiwatana, S.; Zhang, Q.; Spiekermann, K.; Zhuang, J.; Fang, R.; Gao, W.; Obonyo, M.; Zhang, L. "Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection", Advanced Therapeutics 2018, 1, 1800016.
  9. Fang, R.; Kroll, A.; Gao, W.; Zhang, L. "Cell membrane coating nanotechnology", Advanced Materials 2018, 30, 1706759.
  10. Esteban-Fernandez de Avila, B.; Angsantikul, P.; Ramirez-Herrera, D.; Soto, F.; Teymourian, H.; Dehaini, D.; Chen, Y.; Zhang, L., Wang, J. "Hybrid-biomembrane functionalized nanorobots for concurrent removal of pathogenic bacteria and toxins", Science Robotics 2018, 3, eaat0485.
  11. Jiang, Y.; Fang, R.; Zhang, L. "Biomimetic nanosponges for treating antibody-mediated autoimmune diseases", Bioconjugate Chemistry 2018, 29, 870-877.
  12. Angsantikul, P.; Fang, R.; Zhang, L. "Toxoid vaccination against bacterial infection using cell membrane-coated nanoparticles", Bioconjugate Chemistry 2018, 29, 604-612.
  13. Gao, W.; Chen, Y.; Zhang, Y.; Zhang, Q.; Zhang, L. "Nanoparticle-based local antimicrobial drug delivery", Advanced Drug Delivery Reviews 2018, 127, 46-57.
  14. Wei, X.; Ying, M.; Dehaini, D.; Su, Y.; Kroll, A.; Zhou, J.; Gao, W.; Fang, R.; Chien, S.; Zhang, L. "Nanoparticle functionalization with platelet membrane enables multi-factored biological targeting and detection of atherosclerosis", ACS Nano 2018, 12, 109-116.
  15. Li, J.; Angsantikul, P.; Liu, W.; Esteban-Fernandez de Avila, B.; Chang, X.; Sandraz, E.; Liang, Y.; Zhu, S.; Zhang, Y.; Chen, C.; Gao, W.; Zhang, L., Wang, J. "Biomimetic platelet-camouflaged nanorobots for binding and isolation of biological threats", Advanced Materials 2018, 30, 1704800.
  16. Zhang, Y.; Gao, W.; Chen, Y.; Escajadillo, T.; Ungerleider, J.; Fang, R.; Christman, K.; Nizet, V.; Zhang, L. "Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks", ACS Nano 2017, 11, 11923-11930.
  17. Kroll, A.; Fang, R.; Jiang, Y.; Zhou, J.; Wei, X.; Yu, C-L.; Gao, J.; Luk, B.; Dehaini, D.; Gao, W.; Zhang, L. "Nanoparticulate delivery of cancer cell membrane elicits multi-antigenic antitumor immunity", Advanced Materials 2017, 29, 1703969.
  18. Chai, Z.; Hu, X.; Wei, X.; Zhan, C.; Lu, L.; Jiang, K.; Su, B.; Ruan, H.; Ran, D.; Fang, R.; Zhang, L.; Lu, W. "A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin- derived peptide for brain-targeted drug delivery", Journal of Controlled Release 2017, 264, 102-111.
  19. Zhang, Y.; Zhang, J.; Chen, W.; Angsantikul, P.; Spiekermann, K.; Fang, R.; Gao, W.; Zhang, L. "Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection", Journal of Controlled Release 2017, 263, 185-191.
  20. Dehaini, D.; Wei, X.; Fang, R.; Masson, S.; Angsantikul, P.; Luk, B.; Zhang, Y.; Ying, M.; Jiang, Y.; Kroll, A.; Gao, W.; Zhang, L. "Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization", Advanced Materials 2017, 29, 1606209.
  21. Fang, R.; Jiang, Y.; Fang, J.; Zhang, L. "Cell membrane-derived nanomaterials for biomedical applications", Biomaterials 2017, 128, 69-83.
  22. Kroll, A.; Fang, R.; Zhang, L.* “Biointerfacing and applications of cell membrane-coated nanoparticles”, Bioconjugate Chemistry 2017, 28, 23-32.
  23. Wei, X.; Gao, J.; Fang, R.; Luk, B.; Kroll, A.; Dehaini, D.; Zhou, J.; Kim, H. W.; Gao, W.; Lu, W.; Zhang, L.* “Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia”, Biomaterials 2016, 111, 116-123.
  24. Dehaini, D.; Fang, R.; Zhang, L.* “Biomimetic strategies for targeted nanoparticle delivery”, Bioengineering & Translational Medicine 2016, 1, 30-46.
  25. Chen, W.; Zhang, Q.; Luk, B.; Fang, R.; Liu, Y.; Gao, W.; Zhang, L.* “Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function”, Nanoscale 2016, 8, 10364-10370.
  26. Luk, B.; Fang, R.; Hu, C-M.; Copp, J.; Thamphiwatana, S.; Dehaini, D.; Gao, W.; Zhang, K.; Li, S.; Zhang, L.* “Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors”, Theranostics 2016, 6, 1004-1011.
  27. Wang, F.; Fang, R.; Luk, B.; Hu, C-M.; Thamphiwatana, S.; Dehaini, D.; Angsantikul, P.; Kroll, A.; Pang, Z.; Gao, W.; Lu, W.; Zhang, L.* “Nanoparticle-based anti-virulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection”, Advanced Functional Materials 2016, 26, 1628-1635.
  28. Luk, B.; Zhang, L.* “Cell membrane-camouflaged nanoparticles for drug delivery”, Journal of Controlled Release 2015, 220, 600-607.
  29. Gao, W.; Zhang, L.* “Coating nanoparticles with cell membranes for targeted drug delivery”, Journal of Drug Targeting 2015, 23, 619-626.
  30. Angsantikul, P.; Thamphiwatana, S.; Gao, W.; Zhang, L.* “Cell membrane-coated nanoparticles as an emerging antibacterial vaccine platform”, Vaccines 2015, 3, 814-828.
  31. Hu, C-M.; Fang, R.; Wang, K-C.; Luk, B.; Thamphiwatana, S.; Dehaini, D.; Nguyen, P.; Angsantikul, P.; Wen, C.; Kroll, A.; Carpenter, C.; Ramesh, M.; Qu, V.; Patel, S.; Zhu, J.; Shi, W.; Hofman, F.; Chen, T.; Gao, W; Zhang, K.; Chien, S.; Zhang, L.* “Nanoparticle biointerfacing by platelet membrane cloaking”, Nature 2015, 526, 118-121.
  32. Zhang, J.; Gao, W.; Fang, R.; Dong, A.; Zhang, L.* “Synthesis of nanogels via cell membrane-templated polymerization”, Small 2015, 11, 4309-4313.
  33. Wu, Z.; Esteban-Fernandez de Avila, B.; Martin, A.; Christianson, C.; Gao, W.; Thamphiwatana, S.; Escarpa, A.; He, Q.; Zhang, L.; Wang, J. “RBC micromotors carrying multiple cargos towards potential theranostic applications”, Nanoscale 2015, 7, 13680-13686.
  34. Fang, R.; Luk, B.; Hu, C-M.; Zhang, L.* “Engineered nanoparticles mimicking cell membranes for toxin neutralization”, Advanced Drug Delivery Reviews 2015, 90, 69-80.
  35. Pang, Z.; Hu, C-M.; Fang, R.; Luk, B.; Gao, W.; Wang, F.; Chuluun, E.; Angsantikul, P.; Thamphiwatana, S.; Lu, W.; Jiang, X.; Zhang, L.* “Detoxification of organophosphate poisoning using nanoparticle bioscavengers”, ACS Nano 2015, 9, 6450-6458.
  36. Wu, Z.; Li, T.; Gao, W.; Xu, T.; Jurado-Sanchez, B.; Li, J.; Gao, W.; He, Q.; Zhang, L.*; Wang, J. “RBC membrane-coated synthetic nanomotors for effective biodetoxification”, Advanced Functional Materials 2015, 25, 3881-3887.
  37. Wang, F.; Gao, W.; Thamphiwatana, S.; Luk, B.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Fang, R.; Copp, J.; Pornpattananangkul, D.; Lu, W.; Zhang, L.* “Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection”, Advanced Materials 2015, 27, 3437-3443.
  38. Gao, W.; Zhang, L.* “Engineering red blood cell membrane-coated nanoparticles for broad biomedical applications”, AIChE Journal 2015, 61, 738-746.
  39. Gao, W.; Fang, R. H.; Thamphiwatana, S.; Luk, B. T.; Li, J.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Zhang, L.* “Modulating antibacterial immunity via bacterial membrane-coated nanoparticles”, Nano Letters 2015, 15, 1403-1409.
  40. Wu, Z.; Li, T.; Li, J.; Gao, W.; Xu, T.; Christianson, C.; Gao, W.; Galarnyk, M.; He, Q.; Zhang, L.*; Wang, J. “Turning erythrocytes to functional micromotors”, ACS Nano 2014, 8, 12041-12048.
  41. Gao, W.; Thamphiwatana, S.; Angsantikul, P.; Zhang, L.* “Nanoparticle approaches against bacterial infections”, WIREs Nanomedicine & Nanobiotechnology 2014, 6, 532-547.
  42. Copp, J.; Fang, R. Luk, B.; Hu, C-M.; Gao, W.; Zhang, K.; Zhang, L.* “Clearance of pathologic antibodies using biomimetic nanoparticles”, Proceedings of the National Academy of Sciences 2014, 111, 13481-13486.
  43. Hu, C-M.; Zhang, L.* “Nanotoxoid vaccines”, Nano Today 2014, 9, 401-404.
  44. Fang, R.; Hu, C-M.; Luk, B.; Gao, W.; Copp, J.; Tai, Y.; O’Connor, D.; Zhang, L.* “Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery”, Nano Letters 2014, 14, 2181-2188.
  45. Luk, B.; Hu, C-M.; Fang, R.; Dehaini, D.; Carpenter, C.; Gao, W.; Zhang, L.* “Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles”, Nanoscale 2014, 6, 2730-2737.
  46. Hu, C-M.; Fang, R.; Luk, B.; Zhang, L.* “Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies”, Nanoscale 2014, 6, 65-75.
  47. Hu, C-M.; Fang, R.; Luk, B.; Zhang, L.* “Nanoparticle- detained toxins for safe and effective vaccination”, Nature Nanotechnology 2013, 8, 933-938.
  48. Fang, R.; Hu, C-M.; Chen, K.; Luk, B.; Carpenter, C.; Gao, W.; Li, S.; Zhang, D-E.; Lu, W.; Zhang, L.* “Lipid-insertion enables targeting functionalization of erythocyte membrane-cloaked nanoparticles”, Nanoscale 2013, 5, 8884-8888.
  49. Aryal, S.; Hu, C-M.; Fang, R.; Dehaini, D.; Carpenter, C.; Zhang, D-E.; Zhang, L.* “Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release”, Nanomedicine 2013, 8, 1271-1280.
  50. Gao, W.; Hu, C-M.; Fang, R.; Luk, B.; Su, J.; Zhang, L.* “Surface functionalization of gold nanoparticles with red blood cell membranes”, Advanced Materials 2013, 25, 3549-3553.
  51. Hu, C-M.; Fang, R.; Copp, J.; Luk, B.; Zhang, L.* “A biomimetic nanosponge that absorbs pore-forming toxins”, Nature Nanotechnology 2013, 8, 336-340.
  52. Hu, C-M.; Fang, R.; Luk, B.; Chen, K.; Carpenter, C.; Gao, W.; Zhang, K.; Zhang, L.* “ “Marker-of- self” functionalization of nanoscale particles through a top-down cellular membrane coating approach”, Nanoscale 2013, 5, 2664-2668.
  53. Hu, C-M.; Fang, R. H.; Zhang, L.* “Erythrocyte-inspired delivery systems”, Advanced Healthcare Materials 2012, 1, 537-547.
  54. Fang, R. H.; Hu, C-M.; Zhang, L.* “Nanoparticles disguised as red blood cells to evade the immune system”, Expert Opinion on Biological Therapy 2012, 12, 385-389.
  55. Hu, C-M.; Zhang, L.; Aryal, S.; Cheung, C.; Fang, R.; Zhang, L.* “Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform”, Proceedings of the National Academy of Sciences 2011, 108, 10980-10985.